Rabies Encephalopathy in a Pediatric Patient: A Case Report and Recommendations for Community Engagement in Prevention Strategies in Ondo, Nigeria
Keywords:
Community awareness, Dog bite, Nigeria, Post-exposure prophylaxis, Rabies, Rabies encephalopathyAbstract
Rabies is a fatal viral disease affecting the central nervous system. It is transmitted through the saliva of infected mammals, usually via bites, causing confusion, paralysis, and hydrophobia. It is a preventable viral disease that remains a significant public health challenge, especially in developing countries like Nigeria. Prevention is done with immediate wound washing and post-exposure vaccines. Dogs and bats are major vectors globally. We present a case of a 5-year- old female patient diagnosed with rabies encephalopathy following a dog bite. Despite management efforts, including intravenous antibiotics and supportive care, the patient deteriorated and was declared deceased approximately 15 hours post-admission.
References
1. Abubakar AT, Al‐Mustapha AI, Oyewo M, Ibrahim A, Abdulrahim I. Prospects for dog rabies elimination in Nigeria by 2030. Zoonoses and Public Health. 2024;71(1):1-17.
2. Acharya KP, Acharya N, Phuyal S, Upadhyaya M, Lasee S. One-health approach: A best possible way to control rabies. OneHealth. 2020;10:100161.
3. Akankwatsa D, Bagonza A, Kiguli J, Kambugu A, Lamorde M. Barriers to rabies control through mass dog vaccination in rural Uganda: Insights from community perspectives and key informant interviews. PLOS Neglected Tropical Diseases. 2025;19(10):e0013578.
4. Barroga TRM, Basitan IS, Lobete TM, Bernales RP, Gordoncillo MJN. Community awareness on rabies prevention and control in Bicol, Philippines: pre-and post-project implementation. Tropical medicine and infectious disease. 2018;3(1):16.
5. Beran GW. Rabies and infections by rabies-related viruses. Handbook of Zoonoses, Section B. 2017:307-357.
6. Briggs DJ, Moore SM. The route of administration of rabies vaccines: comparing the data. Viruses. 2021;13(7):1252.
7. Changalucha J, Steenson R, Grieve E, Cleaveland S, Lembo T. The need to improve access to rabies post-exposure vaccines: lessons from Tanzania. Vaccine. 2019;37: A45-A53.
8. Chen Q, Cai L, Lv X, Liu S, Liu C. Circulating Antibody's Role During Post-Exposure Prophylaxis, and Beyond for Rabies: A Review. Vaccines. 2025;13(7):775.
9. Fatima M, Iqbal T, Shaheen L, Salma U, Siddique R. Transmission dynamics of rabies virus. Int J Agric Biosci. 2023;3:386-97.
10. Hemachudha P, Hemachudha T. Rabies: Presentation, case management and therapy. Journal of the Neurological Sciences. 2021:424.
11. Marjiana T, Astari AM, Zuhriyah L. Systematic review of community efforts in early handling post-exposure prophylaxis cases of rabies animal bite transmission. International Journal of PublicHealth. 2021;10(1):127-135.
12. Mshelbwala PP, Weese JS, Sanni-Adeniyi OA, Chakma S, Okeme SS. PLoS neglected tropical diseases. 2021;15(8): e0009617.
13. Nadal D, Bote K, Masthi R, Narayana A, Ross Y. Rabies post-exposure prophylaxis delivery to ensure treatment efficacy and increase compliance. IJI Done Health. 2023;1:100006.
14. N'Guessan RD, Heitz-Tokpa K, Amalaman DM, Tetchi SM, Kallo V. Determinants of rabies post-exposure prophylaxis drop-out in the region of San-Pedro, Côte d'Ivoire. Frontiers in Veterinary Science. 2022; 9(8): 78-88.
15. Oloko OK. Factors Associated with Vaccine Uptake: A Study on Rabies Post-Exposure Prophylaxis in The Philippines. London School of Hygiene & Tropical Medicine.2023.
16. Rabies epidemiology, prevention and control in Nigeria: Scoping progress towards elimination
17. Rather MM, Vasavi K. Unleashing the Truth: Understanding Rabies in Humans and Animals. Emerging Human Viral Diseases, VolumeII: Encephalitic, Gastroenteric, and Immunodeficiency Viral Infections. 2024:289-306.
18. Sikana L, Lembo T, Hampson K, Lushasi K, Mtenga S. Dog ownership practices and responsibilities for children's health interms of rabies control and prevention in rural communities in Tanzania. PLoS neglected tropical diseases. 2021;15(3):e0009220.
19. Swedberg C, Bote K, Gamble L, Fénelon N, King A, Wallace RM. Eliminating invisible deaths: the woeful state of global rabies data and its impact on progress towards 2030 sustainable development goals for neglected tropical diseases. Frontiers in tropical diseases. 2024;5:1303359.
20. Swedberg C, Mazeri S, Mellanby RJ, Hampson K, Chng NR. Implementing a one health approach to rabies surveillance: lessons from integrated bite case management. Frontiers in tropical diseases. 2022;3:829132.
21. Taylor LH, Wallace RM, Balaram D, Lindenmayer JM, Eckery DC. The role of dog population management in rabies elimination—a review of current approaches and future opportunities. Frontiers in veterinary science. 2017;4:109.
22. World Health Organization. Rabies vaccines: WHO position paper, April 2018–Recommendations. Vaccine. 2018;36(37):5500-5503.
23. Zha R, Lu J, Chen J, Guo C, Lu J. Exploring one health based strategies for rabies elimination: Overview and future prospects. PLOS Neglected Tropical Diseases. 2025;19(6):e0013159.
